Endovascular Revascularization Plus Supervised Exercise Versus Supervised Exercise Only for Intermittent Claudication: A Cost-Effectiveness Analysis

Background: The ERASE (Endovascular Revascularization and Supervised Exercise) study showed that a combination therapy of endovascular revascularization followed by supervised exercise resulted in greater improvement walking ability quality life as compared with only (standard care) patients intermittent claudication. cost-effectiveness the is not well defined. In this report, analysis presented. Methods: Two hundred twelve were randomly assigned to (n=106) or for 12 months. Cumulative costs per patient collected using in-hospital resource utilization data cost-questionnaires. Quality-adjusted years estimated EuroQol-5D questionnaire. Incremental ratios calculated from both health care societal perspective. associated uncertainty was determined bootstrap techniques acceptability curves. Results: As only, cost an additional €1.462 (99% CI, 388 3862) perspective €161 −2286 3106) Accumulated quality-adjusted life- during 1 year follow-up 0.042 −0.009 0.118) higher group. incremental ratio €34.810 €3.833 Compared exercise, at willingness-to-pay threshold €80.000 life-year, had probability 87% 95% being cost-effective perspective, respectively. Conclusions: Combination clinically economically more attractive approach than claudication up 12-month follow-up. Yet, long-term cost- clinical effectiveness strategies specific groups remains be Registration: URL: https://www.trialregister.nl ; Unique identifier: NTR2249.